Evaluation of antidiabetic and hepatoprotective activities of ethanolic extract of the fruits of eriobotrya japonica in streptozotocin induced diabetic rats (Funded work)

Abstract

The aim of the present  study was   to observe the  antidiabetic  and hepatoprotective    activities  of ethanolic extract  of  Eriobotrya  japonica  fruits  in streptozotocin  induced  diabetic rats. The phytochemical screening of the plant was also done. The animals were divided into   five groups. Normal Control group   received only the vehicle. Toxic group   included those animals in which diabetes was induced by streptozotocin. The 3^rd group of animals received streptozotocin and standard antidiabetic drug-glibenclamide. The 4^th group included those   diabetic animals which received   50 mg/kg b.w dose of fruits of Eriobotrya japonica extract.  The 5^th  group of  animals  included  those diabetic  animals which  received  100 mg/kg b.w  of the plant  extract. The  biochemical  parameters  that were  evaluated  includes  blood  glucose  levels and  liver function tests. At the end, the animals were sacrificed and histopathology of pancreas and liver was also done. The results showed significant decrease in blood glucose levels, when treated with two different doses of the plant extract. There  was reduction in  liver  function tests also  in animals .The extract of  Eriobotrya japonica  fruits  have shown significant antidiabetic  and hepatoprotective  activities attributed  to its antidiabetic and  hepatoprotective potential.