Potency of injectable hydroxyapatite chitosan (ihac) scaffold for rabbit femoral condyle defect regeneration - Paper Withdrawn

Abstract

Objective of this study is to evaluate the effect of Injectable Hydroxyapatite Chitosan Scaffold (IHAC) for
rabbit femoral condyle bone regeneration by assessing its histological view. The experiment was
conducted in New Zealand White Rabbits. Injectable Hydroxyapatite Chitosan Scaffold (IHAC) scaffold
was transplanted into the femoral defect which had been prepared. Bone regeneration was analyzed
histologically using Modified Salkeld Histological Scoring four weeks postoperatively. The results indicate
that cortical bone fusion occurred better in the treated rabbit compared to control rabbit. In the treated
rabbit, active osteoblast lined in the peripheral of mature bone. Cortical bone has underwent complete
maturation. Control rabbit still showed the presence of hematoma and fibrocartilage that indicated earlyphase
of bone regeneration. In conclusion, Injectable Hydroxyapatite Chitosan (IHAC) scaffold is potential
for treatment of bone defect by guiding the host response to regenerate the bone tissue.