Synthesis and biological evaluation of azetidinone derivatives as antibacterial and Antifungal agents

Abstract

We have developed a novel approach for the preparation of N-[(Z)-arylmethylidene] pyrrolidine-2-carboxamide using catalytic acetic acid through the reaction of different substituted benzaldehyde with L-Prolinamide. These molecules were further cyclized with chloroacetylchloride under nucleophilic substitution reaction condition to finally afford 3-chloro-4-aryL-1-[(2S)-pyrrolidin-2-ylcarbonyl]azetidin-2-one. These synthesized compounds were further confirmed by IR, ¹H NMR, and mass spectroscopy. All these final synthesized compounds have been screened for their biological activity against different strains for their antibacterial and antifungal activity.