Sulphur dioxid induced hematotoxicity and its melioration by emblicaofficinalis in rattusnorvegicus (berkenhout)

Abstract

Present study was designed  to investigate the adverse effects of SO₂ on hematology in terms of  total leucocyte count [TLC] and differential leucocyte count [DLC] – monocyte count, lymphocyte count, neutrophil count, basophil count and eosinophil count, besides, modulatory effects of Emblica officinalis (Amla) in albino rat. The rats of both sexes were kept in standard laboratory conditions and grouped as- control group (1) kept away from exposed rats for 30 & 60 days, experimental group (2) exposed to 80ppm SO₂ gas (1h/d) for 30 & 60 days and experimental group (3) exposed to 80ppm SO₂ gas (1h/d) with oral supplementation of aqueous extract of Emblica officinalis (200mg/rat/day) for 30 & 60 days. The findings of the present study showed a significant increase in total leucocyte count, besides, decrease in differential leucocyte count with an increase in neutrophil count is the result of inflammation due to toxic action of SO₂ gas. However, SO₂ induced alterations were meliorated after supplementation of aqueous extract of Emblica officinalis due to its antioxidant and anti-inflammatory activity, in albino rats.