IN VIVO ANTI OXIDATIVE EFFECT OF POLYHERBAL FORMULATION OF FLAX SEED, FENUGREEK AND JAMUN SEED ON STREPTOZOTOCINNICOTINAMIDE INDUCED DIABETIC RATS

Authors

  • S.LATHA Department of Physiology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.c
  • R.VIJAYAKUMAR Department of Physiology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.
  • B.R.SENTHIL KUMAR Department of Physiology, National Siddha institute, Tambaram, Chennai, India.
  • R.SRIKUMAR Centre of research, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.

Keywords:

Antioxidants, PHF, Streptozotocin, Nicotinamide

Abstract

Oxidative stress is the main cause of the secondary complications in diabetes mellitus (DM). The aim of
this study is to evaluate the antioxidative effect of polyherbal formulation (PHF) of hydroalcoholic extracts
of flaxseed, fenugreek, jamun seed (1:1:1) and their individual drugs in Streptozotocin-Nicotinamide
induced DM in wistar rats. The drugs were given orally at dose of 200mg/kg body weight (bw )for 30
days .On 31st day liver were isolated and homoginized in Tris-HCl buffer for measurement of
antioxidants. The result shown that significant (p<0.05) increase in lipid peroxidation and decrease in
suproxide dismutase, catalase, glutathione peroxidase, glutathione s transferase, glutathione reductase,
vitamin C, vitamin E level in diabetic animals. The treatment with PHF and their individual drugs
significantly reversed these changes. The PHF treated group shown greater percentage changes than
their individual drugs treated groups. This concludes PHF has greater antioxidative effect and the
synergism exist between their individual drugs.

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Published

2016-12-31

How to Cite

S.LATHA, R.VIJAYAKUMAR, B.R.SENTHIL KUMAR, & R.SRIKUMAR. (2016). IN VIVO ANTI OXIDATIVE EFFECT OF POLYHERBAL FORMULATION OF FLAX SEED, FENUGREEK AND JAMUN SEED ON STREPTOZOTOCINNICOTINAMIDE INDUCED DIABETIC RATS. International Journal of Pharma and Bio Sciences, 7(4), 607–611. Retrieved from https://ijpbs.in/index.php/journal/article/view/5525

Issue

Volume 7, Issue 4, 2016

Section

Research Articles

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