ANTIMICROBIAL ACTIVITIES AND THE FIRST ISOLATION OF 4-NITROBENZOIC ACID TETRAHYDROFURAN-2-YL-METHYLESTER AND 4-HYDROXY-5-METHYLFURAN-3-ONE FROM TERRESTRIAL STREPTOMYCES SP.

Authors

  • SAYED A. AHMED Chemistry Department, Faculty of Science, Beni Suef University, Salah Salem Street, P.O. 62514, Beni Suef, Egypt.
  • MAHMOUD AL-REFAI Department of Chemistry, Faculty of Science, Al Al-Bayt University, Mafraq, 25113, Jordan.
  • ALZAHRAA OSAMA Chemistry Department, Faculty of Science, Beni Suef University, Salah Salem Street, P.O. 62514, Beni Suef, Egypt.
  • EMADELDIN M. KAMEL Chemistry Department, Faculty of Science, Beni Suef University, Salah Salem Street, P.O. 62514, Beni Suef, Egypt.

Keywords:

Terrestrial streptomycetes, Nitrobenzoic acid derivative, Furanone, Natural products.

Abstract

In our investigation of the crude extracts from the terrestrial derived Streptomycete isolate sp. Wo 990, two compounds namely, 4-nitrobenzoic acid tetrahydrofuran-2-yl-methylester (1) and 4-hydroxy-5- methylfuran-3-one (5) were obtained for the first time from microorganisms. In addition, 2- phenylacetamide, 5-methyl-1H-pyrimidine-2,4-dione, 2-amino-3-phenyl-propionic acid and 2-(6-aminopurin-9-yl)-5-methyl-sulfanylmethyl-tetrahydrofuran-4-diol were isolated. The structures of the new compounds 1 and 5 were elucidated on the basis of spectroscopic analysis (1D and 2D), mass spectra and comparison with the literature data.

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Published

2016-03-31

How to Cite

SAYED A. AHMED, MAHMOUD AL-REFAI, ALZAHRAA OSAMA, & EMADELDIN M. KAMEL. (2016). ANTIMICROBIAL ACTIVITIES AND THE FIRST ISOLATION OF 4-NITROBENZOIC ACID TETRAHYDROFURAN-2-YL-METHYLESTER AND 4-HYDROXY-5-METHYLFURAN-3-ONE FROM TERRESTRIAL STREPTOMYCES SP. International Journal of Pharma and Bio Sciences, 7(1), 45–55. Retrieved from https://ijpbs.in/index.php/journal/article/view/4837

Issue

Volume 7, Issue 1, 2016

Section

Research Articles

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