HEPATIC AND HEMATOLOGICAL ACTIVITIES OF HYDRO-ALCOHOLIC EXTRACT OF ERIOBOTRYA JAPONICA FRUITS IN SWISS ALBINO MICE

Abstract

The  hydro-alcoholic  extract  of fruits  of  Eriobotrya  japonica  was  evaluated  for  its  toxicity  on  hepatic  and  hematological  parameters  in swiss albino  mice.  Animals of  either sex  were  treated  with  different  doses  of the  extract  for  its  acute  toxicity  tests.  The  doses  taken  were  500,1000,1500,2000 mg/kg. In  this  LD₅₀  was  calculated. After  finding  the LD₅₀, optimum  dose  for  sub-acute  toxicity  studies  were taken.  The  effect  of the  plant  extract on  hepatic  and  hematological  parameters  were  taken  into consideration. The  doses taken were 250 and  500 mg/kg  b.w. Histopathology  of  liver and  spleen  were also  done. The  results  shows  that  in  acute  toxicity  studies, it  showed  that LD₅₀ was  500mg/kg b.w and   in  sub-acute  studies it  showed  variable  biochemical  parameters  with  no  toxicity on liver and  spleen.