EFFECT OF EMBLICA OFFICINALIS (AMLA) ON APOPTOTIC CELL DEATH FOLLOWING ISCHEMIA REPERFUSION INJURY IN RATS

Authors

  • DINESH TRIPATHI Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India
  • ARTI VERMA Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India
  • SANDEEP BHATTACHARYA Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India
  • SUNITA TIWARI Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India

Keywords:

Apoptosis, Ischemia, Flow cytometry, Rats

Abstract

Cell death following ischemia reperfusion injury leads to life threatning problems in patients suffering from cerebral stroke. The aim of this study was to investigate the neuroprotective effects of Emblica Officinlis (amla) fruit extract on neuronal apoptosis following cerebral ischemia reperfusion injury.1 hour ischemia followed by 24 hours reperfusion, rats were orally administered amla fruit extract. Apoptotic cells in brain were determined by performing flow cytometry. The results showed that amla extract significantly decreased the apoptotic cells by flow cytometry 24 hours after the ischemic injury compared with the MCAO group. This study suggests that amla may be used for treatment of ischemic stroke as a neuroprotective agent.

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Published

2015-09-30

How to Cite

DINESH TRIPATHI, ARTI VERMA, SANDEEP BHATTACHARYA, & SUNITA TIWARI. (2015). EFFECT OF EMBLICA OFFICINALIS (AMLA) ON APOPTOTIC CELL DEATH FOLLOWING ISCHEMIA REPERFUSION INJURY IN RATS. International Journal of Pharma and Bio Sciences, 6(3), 81–87. Retrieved from https://ijpbs.in/index.php/journal/article/view/4443

Issue

Volume 6, Issue 3, 2015

Section

Research Articles

Categories

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