DIFFERENTIAL EFFECTS OF ALLOXAN ON DIFFERENT BLOOD PARAMETERS IN DIABETEC INDUCED MALE WISTAR RATS

Abstract

Alloxan is known for chemical induction of Type 1 Diabetes Mellitus (DM) through
selective damage of β- cells of pancreas, thereby inducing hyperglycemic state in
experimental animals. Adult male wistar rats were used as experimental models.
Diabetes was induced by injecting alloxan monohydrate at a dose of 60 mg/kg body
weight for three days daily. The physical parameters like body weight showed a
significant decline whereas there was a rise in food consumption and water intake of the
experimental animals. The blood parameters like blood glucose, SGPT, SGOT, and
LDH and creatinine levels showed an increase. Blood glucose, LDH and creatinine
showed a statistically significant result. However, SGPT and SGOT were statistically
insignificant. The study indicates that physical and blood serum parameters might serve
as a good indicator for the study of physiology and effects in alloxan induced diabetic
rats.