AN UNUSUAL CAUSE OF ACUTE INTERSTITIAL NEPHRITIS

Abstract

Multiple myeloma is a monoclonal proliferation of B-cell lineage, often referred to as plasma cell dyscrasias. Early diagnosis, is of immense importance because initiation of treatment at early stage has a vital role in the prognosis. This case was presented to enlighten an uncommon cause of acute interstitial nephritis.A 55 year old Indian women presented to medical outpatient department with epigastric discomfort and non oliguric renal failure .Investigation reports revealed non nephrotic range protienuria ,elevated urine eosinophils, urine bencejonce protein was positive, serum electrophoresis revealed M band and immunofixation confirmed multiple myeloma .Kidney biopsy  was done and patient was diagnosed to have  myeloma kidney. Patient found to have elevated serum beta-2-microglobulin and a reduced serum albumin which suggests poor prognosis. The patient is on chemotherapy and on regular follow up. Recognition of the disease before the onset of complications and early initiation of therapy offers good prognosis as it can prolong lifespan and prevent fatal complications.