SYNTHESIS, REPRECIPITATION METHOD AND PHARMACOLOGICAL POTENCY OF FREE PORPHYRIN BASED NANOPARTICLES

Authors

  • RASHA E. EL-MEKAWY Department of Petrochemicals, Egyptian Petroleum Research Institute, Nasr City, Cairo, Egypt Department of Chemistry, Faculty of applied Science, Umm Al-Qura University, Makkah Al - Mukarrama, Saudi Arabia
  • SRAA ABU-MELHA Faculty of Science of Girls, King Khaled University, Abha, Saudi Arabia

Keywords:

Pyrrole, Porphyrin, porphyrin nanoparticles, Antitumor activity

Abstract

We have designed and synthesized a new symmetrical porphyrins 3a-d and their nanoparticles based on extended π-conjugation concept. The new sensitizers were fully characterized by CHN analysis, UV-Vis., 1H-NMR, TEM and Mass spectroscopy. The new sensitizers and their nanoparticles were evaluated as antitumor activity against HepG2, WI-38, VERO and MCF-7  cell lines. It was found that porphyrin nanoparticles have the most potent activity.

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Published

2014-12-31

How to Cite

RASHA E. EL-MEKAWY, & SRAA ABU-MELHA. (2014). SYNTHESIS, REPRECIPITATION METHOD AND PHARMACOLOGICAL POTENCY OF FREE PORPHYRIN BASED NANOPARTICLES. International Journal of Pharma and Bio Sciences, 5(4), 501–515. Retrieved from https://ijpbs.in/index.php/journal/article/view/3687

Issue

Volume 5, Issue 4, 2014

Section

Research Articles

Categories

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