PHYTOCHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF HOMALIUM ZEYLANICUM BENTH.

Authors

  • RACHALA VINOD KUMAR CSIR-Central Institute of Medicinal and Aromatic Plants-Research Centre, Boduppal, Hyderabad-500092, AP, India.
  • KATAKAM BABITHA CSIR-Central Institute of Medicinal and Aromatic Plants-Research Centre, Boduppal, Hyderabad-500092, AP, India.
  • NIRANJAN KUMAR CSIR-Central Institute of Medicinal and Aromatic Plants-Research Centre, Boduppal, Hyderabad-500092, AP, India.
  • KVNS SRINIVAS CSIR-Central Institute of Medicinal and Aromatic Plants-Research Centre, Boduppal, Hyderabad-500092, AP, India.
  • J KOTESH KUMAR CSIR-Central Institute of Medicinal and Aromatic Plants-Research Centre, Boduppal, Hyderabad-500092, AP, India.
  • SHAILENDRA PRATAP SINGH CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad-500007, AP, India
  • PARAMJIT GROVER CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad-500007, AP, India

Keywords:

Homalium zeylanicum, Antioxidant activity, Anticancer activity, Phenolic compounds.

Abstract

Homalium zeylanicum is a rare and phytochemically less explored tropical tree. Chemical examination of bark and leaf of this species yielded phenolic compounds 3-Phenyl coumarin (1) and 4'-O-Methyl-Epigallo catechin (2). The structures of the compounds were established on the basis of various NMR spectral data. The extracts of bark, leaf and their isolated compounds showed both antioxidant and anticancer activities in in vitro mode. The acetate derivative of compound 2 showed significant anticancer activity against human cancer cell line IMR-32 (IC50 6.26 µg/ml) in the MTT assay.

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Published

2014-09-30

How to Cite

RACHALA VINOD KUMAR, KATAKAM BABITHA, NIRANJAN KUMAR, KVNS SRINIVAS, J KOTESH KUMAR, SHAILENDRA PRATAP SINGH, & PARAMJIT GROVER. (2014). PHYTOCHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF HOMALIUM ZEYLANICUM BENTH. International Journal of Pharma and Bio Sciences, 5(4), 176–182. Retrieved from https://ijpbs.in/index.php/journal/article/view/3269

Issue

Volume 5, Issue 3, 2014

Section

Research Articles

Categories

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