SPECTRAL CHARACTERIZATION DNA - BINDING STUDIES AND BIOLOGICAL ACTIVITY OF CR(III), CO(II), NI(II), HG(II) AND CD(II) COMPLEXES WITH NICOTINIC ACID HYDRAZIDE AND THIOCYANATE ION AS LIGANDS

Authors

  • BALASUBRAMANIYAN S Govt. Arts College (Autonomous), Karur – 639 005, INDIA
  • PAULRAJ. A St. Joseph’s College (Autonomous), Tiruchirappalli- 620002, INDIA
  • RAMACHANDRAMOORTHY.T P.G and Research Department of Chemistry, Bishop Heber College (Autonomous), Tiruchirappalli-620 017, India

Keywords:

Nicotinicacidhydrazide, antifungal, thiocynate ion, DNA

Abstract

The complexes of Cr(III) , Co(II), Ni(II), Hg(II), Cd(II) were synthesized with the ligands
Nicotinicacidhydrazide and (SCN-) and characterized by using Elemental analysis,
Molar conductance measurements, IR, NMR, spectroscopic studies,all the complexes
are identified as bidentate forms chelate complexes.Gel electrophoresis study reveals
the fact that the copper complex cleaves super coiled pBR 322 DNA to nickel and linear
forms in the presence and absence of nicotinic acid hydrazide. Antibacterial and
antifungal activities of the complexes were studied and the complexes were screened
against bacteria and fungi. The fungal activity data shows that the metal complexes are
potent active than the parent ligand NHA.

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Published

2014-03-31

How to Cite

BALASUBRAMANIYAN S, PAULRAJ. A, & RAMACHANDRAMOORTHY.T. (2014). SPECTRAL CHARACTERIZATION DNA - BINDING STUDIES AND BIOLOGICAL ACTIVITY OF CR(III), CO(II), NI(II), HG(II) AND CD(II) COMPLEXES WITH NICOTINIC ACID HYDRAZIDE AND THIOCYANATE ION AS LIGANDS. International Journal of Pharma and Bio Sciences, 5(1), 773–781. Retrieved from https://ijpbs.in/index.php/journal/article/view/3191

Issue

Volume 5, Issue 1, 2014

Section

Research Articles

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