IN SILICO ANALYSIS OF INTERLEUKIN-2: A COMPARATIVE STUDY BETWEEN HOMO SAPIENS AND MUS MUSCULUS

Authors

  • NEHA SINGH School of BioSciences and Technology, VIT University, Vellore-632014, Tamil Nadu, India.
  • AKRITI JAIN School of BioSciences and Technology, VIT University, Vellore-632014, Tamil Nadu, India.
  • ANAND ANBARASU School of BioSciences and Technology, VIT University, Vellore-632014, Tamil Nadu, India.

Keywords:

Interleukin 2, Physio-chemical properties, Topology mapping, Solvent accessible area, Stabilizing Centre and Stabilizing Residue

Abstract

Homo sapiens and Mus musculus genomes have the similarity ranges from 70% to 90% with an average of 85%. Interleukin (IL) has 17 different families among which interleukin 2 (IL2) is present in both Homo sapiens and Mus musculus. IL2 activates the receptor named IL2-R which further proliferate lymphocytes such as T-cell and B-cell. IL2 is a glycosylated polypeptide lymphokine. It requires cleavage of the signal sequence for its activity. IL2 is used for immunotherapy to treat cancer and its suppression avoids autoimmunity in patients with transplantations. IL2 of Homo sapiens and Mus musculus are studied and analysed using simulation and structural analysis methods. The results are compared to obtain their similarity profile. This result can further be applied in the study of inflammatory disease related aspects in future.

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Published

2013-12-31

How to Cite

NEHA SINGH, AKRITI JAIN, & ANAND ANBARASU. (2013). IN SILICO ANALYSIS OF INTERLEUKIN-2: A COMPARATIVE STUDY BETWEEN HOMO SAPIENS AND MUS MUSCULUS. International Journal of Pharma and Bio Sciences, 4(4), 902–909. Retrieved from https://ijpbs.in/index.php/journal/article/view/2824

Issue

Volume 4, Issue 4, 2013

Section

Research Articles

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