ANTIDIABETIC ACTIVITY OF AQUEOUS EXTRACT OF PARKINSONIA ACULEATA IN ALLOXAN INDUCED DIABETIC RATS, WITH EMPHASIS ON DIABETIC COMPLICATIONS

Abstract

The present study focused on antidiabetic effect of Aqueous leaf extract of Parkinsonia aculeata in alloxan induced diabetic rats using Metformin as (positive control). The parameters measured were blood glucose, hepatic glycogen, triglycerides, SGOT, SGPT, Creatinine, LDL, CRP and urea, Emphasis was on evaluating effect of Aqueous leaf extract in Diabetic Neuropathy and memory dysfunction in rats using various behavioural models. Oral administration of Aqueous extract in dose of (500 mg/kg) for 18 days exhibited a significant reduction in Bld glucose, urea, triglycerides etc as compared to negative control. Also it was found to be very effective in preventing Diabetic neuropathy and memory dysfunction.The effects of Aqueous leaf extract on the metabolic and behavioural parameters was comparable to those observed in diabetic Metformin  treated group. The results suggest that P. aculeata can be new clinical significant choice in diabetes mellitus and its complications.