EVALUATION OF ACTIVITY OF WHOLE STEM EXTRACTS OF OROXYLUM INDICUM ON PARACETAMOL INDUCED HEPATOTOXICITY.

Abstract

The objective of the present study was to evaluate the activity of the aqueous and ethanolic whole stem extracts of Oroxylum indicum in hepatic injury produced with paracetamol.Wistar albino rats were used for the study.Multiple groups were taken for the study each consisting of six rats. Liver injury was induced using paracetamol 2 gm/kg, p.o.as a single dose. The two control groups received oral 1% CMC for 7 days, one of this group received paracetamol on 8^th day. The four test groups received aqueous and ethanolic extracts of Oroxylum indicum at two different dose levels of 250mg/kg and 500mg/kg (p.o.) respectively for 7 days, followed by the paracetamol administration on day 8, Standard control group received Silymarin as a comparable drug followed by Paracetamol. The serum parameters for liver such as ALT, AST, LDH, ALP, TB and TP were assessed along with the liver antioxidant enzymes LPO, Catalase and GSH. The histopathology analysis of liver was done on 8^th day after due sacrificing the rats. Marker enzymes were analyzed in liver tissue. Both the extracts showed significant hepatoprotective activity comparable to that of Silymarin.