1,5-BENZODIAZEPINE: A VERSATILE PHARMACOPHORE

Abstract

Diazepines are an eminent class of drugs owing to their psychotherapeutic activities. Among these, 1,5-benzodiazepines are regarded as privileged structures due to their clinical importance and commercial success. Although immense work has been carried out on the benzodiazepine nucleus, it continues to receive a great deal of attention. Due to their vast range of biological properties the benzodiazepine nucleus has fascinated many investigators to synthesize and screen the analogues for all possible activities through all possible routes. This current review article mainly covers the various routes of synthesis utilized, the numerous solvents employed, catalysts used and the different pharmacological activities exhibited by 1,5-benzodiazepine derivatives. This review encompasses the research work that has been accomplished since the past decade.