EVALUATION OF ANTI-INFLAMMATORY, ANTIDIABETIC, CYTOTOXIC ACTIVITY OF KAPPAPHYCUS ALVAREZII

Abstract

In recent years, a significant number of novel metabolites with potent pharmacological properties (antioxidant, antitumor, anti-HIV etc.) have been discovered from the marine organisms. Kappaphycus alvarezii (Doty). Being an invasive in the Gulf of Mannar after 2000 AD, has high content of steroid, phenol etc., this work was the first report of its medical application. The present study investigated the medicinal valve of red alga Kappaphycus alvarezii using in vitro studies. The algal methanol extract was screened for its antidiabetic evaluated by α- amylase; anti-inflammatory activity using hyaluronidase inhibition and cytotoxicity against the stannous chloride in E. coli AB 1157. Chemical structures of the isolated compound from the thalli of K. alvarezii were established by spectral techniques (UV, 125 H NMR). The methanol extract of K. alvareziis showed potent α-amylase inhibition activity than anti-inflammatory activity. The screening results suggested that the algal can be processed further analysis using animal models.