PHYSICO-CHEMICAL STUDIES ON STABILITY OF CLOPIDOGREL TABLET FORMULATIONS

Authors

  • SANJEEVA YARKALA Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, India.Analytical Chemistry Department, ISP (India) Private Ltd., Somajiguda, Hyderabad 500 082, India.
  • SIVAKUMAR A Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, India.
  • SAMEER G. NAVALGUND Analytical Chemistry Department, ISP (India) Private Ltd., Somajiguda, Hyderabad 500 082, India.

Keywords:

Clopidogrel tablets, PVPP XL, LHPC and Stability

Abstract

Clopidogrel bisulphate (anti-coagulant drug) is an enantio-selective chrial drug and needs to be monitored for the active form in tablet formulation. Hence, a stable tablet formulation was developed for clopidogrel using two different disintegrants of LHPC (to match as closely as possible to innovator tablet) and PVPP XL. Tablets were evaluated for stability analysis using validated analytical methods. The results showed similar drug release profile and assay on stability. Clopidogrel R-isomer was detected in both LHPC and PVPP XL containing  tablet formulations and it was found to be less than 2.5% after six months  stability study under accelerated conditions which is simulation of  three  years storage period

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Published

2012-12-31

How to Cite

SANJEEVA YARKALA, SIVAKUMAR A, & SAMEER G. NAVALGUND. (2012). PHYSICO-CHEMICAL STUDIES ON STABILITY OF CLOPIDOGREL TABLET FORMULATIONS. International Journal of Pharma and Bio Sciences, 3(4), 433–439. Retrieved from https://ijpbs.in/index.php/journal/article/view/1695

Issue

Volume 3, Issue 4, 2012

Section

Research Articles

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