Pharmacokinetic And Pharmacodynamic Interaction Between Aceclofenac And Rosiglitazone In Rats

Authors

  • R. SATHISH Department of Nanju Noolum Maruthuva Neethi Noolum, NIS, Chennai -600114
  • J. ANBU Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, (VISTAS) Vels
  • ASHWINI ANJANA 1Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, (VISTAS) Vels University, Pallavaram, Chennai-600117 India
  • K.F.H. NAZEER AHAMED Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, (VISTAS) Vels University, Pallavaram, Chennai-600117 India
  • G.SRINIVASA RAO Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, (VISTAS) Vels University, Pallavaram, Chennai-600117 India

Keywords:

Drug interaction, Cox-inhibitors, Aceclofenac, Rosiglitazone, Rheumatoid arthritis and Diabetics

Abstract

The present study was carried out to investigate the pharmacokinetics and pharmacodynamic interaction of Aceclofenac and Rosiglitazone alone and their combination in rats. The animals were maintained on standard laboratory conditions and were divided into 3 and 6 groups for pharmacokinetic and pharmacodynamic studies respectively. Aceclofenac and Rosiglitazone alone produced antiarthritic and marked reduction in blood glucose levels (Antidiabetic) respectively but their combination produced a decreased efficiency of rosiglitazone for antidiabetic activity and increased antiarthritic activity of aceclofenac when co-administered with Rosiglitazone.

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Published

2012-06-30

How to Cite

R. SATHISH, J. ANBU, ASHWINI ANJANA, K.F.H. NAZEER AHAMED, & G.SRINIVASA RAO. (2012). Pharmacokinetic And Pharmacodynamic Interaction Between Aceclofenac And Rosiglitazone In Rats. International Journal of Pharma and Bio Sciences, 3(2), 385–394. Retrieved from https://ijpbs.in/index.php/journal/article/view/1347

Issue

Volume 3, Issue 2, 2012

Section

Research Articles

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