Wound Healing Activity Of Topical Application Of Aloe Vera Gel In Experimental Animal Models

Authors

  • K.C.HARITHA YADAV Department of Pharmacology, Kamineni Institute of Medical Sciences, Nalgonda, India.
  • J. RAVI KUMAR Department of Pharmacology, SVS Medical College, Mahabubnagar, India.
  • S.ILIAS BASHA Department of Pharmacology, SVS Medical College, Mahabubnagar, India.
  • G.R.DESHMUKH Department of Pathology, Aptus Biosciences, Mahabubnagar, India.
  • RAVI GUJJULA Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, India.
  • B.SANTHAMMA Department of Pharmacology, Kamineni Institute of Medical Sciences, Nalgonda, India.

Keywords:

Aloe vera gel, wound healing activity, wound excision model, collagen

Abstract

Aloe vera gel of 50% and 96.4% were tested for its wound healing activity by topical application in experimental rats. The effect of Aloe vera gel on wound healing was evaluated by wound excision model and histopathology was used to study the effect on wound healing. The effect produced by Aloe vera gel with reference to wound contraction, wound closure, decrease in surface area of wound, tissue regeneration at the wound site and histopathological characteristics were  significant in treated rats. The effect of Aloe vera gel on biochemical studies revealed significant increase in collagen and decreased hexosamine content and malondialdehyde levels when compared with control. The present study thus provided scientific rationale for the traditional use of Aloe vera gel for management of wounds.

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Published

2012-06-30

How to Cite

K.C.HARITHA YADAV, J. RAVI KUMAR, S.ILIAS BASHA, G.R.DESHMUKH, RAVI GUJJULA, & B.SANTHAMMA. (2012). Wound Healing Activity Of Topical Application Of Aloe Vera Gel In Experimental Animal Models. International Journal of Pharma and Bio Sciences, 3(2), 63–72. Retrieved from https://ijpbs.in/index.php/journal/article/view/1311

Issue

Volume 3, Issue 2, 2012

Section

Research Articles

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