Oxidative Stress In Myocardial Infarction

Abstract

Myocardial Infarction  results from occlusion of the coronary artery and reactive oxygen species  have an important role in the pathogenesis of myocardial infarction. The study population contained 56 subjects with Acute myocardial infarction divided into four groups, Group  I ,11 patients with  Diabetes Mellitus and  Hypertension, Group II ,11 patients with Hypertension, Group III 17 patients  Non smokers, Group IV 17 patients  Smokers and  30 age and sex matched healthy subjects were investigated for Troponin I , Creatine Kinase, CKMB , Lipid profile and plasma MDA .  Plasma MDA levels were significantly elevated in all the groups(p<0.001). Study revealed a significant positive association between plasma MDA and Cholesterol (p<0.01;r=0.620) and plasma MDA and Triglycerides (p<0.01;r=0.028) and a negative association between MDA and  HDL-cholesterol (p<0.01; r=0.006). A significant increase in MDA and  a significant decrease of HDL-C suggest that reactive oxygen species have an important role in the pathogenesis of myocardial infarction.